Thyroid Transcription Factor in Differentiating Type II Cells
نویسندگان
چکیده
منابع مشابه
Thyroid transcription factor in differentiating type II cells: regulation, isoforms, and target genes.
Thyroid transcription factor-1 (TTF-1, product of the Nkx2.1 gene) is essential for branching morphogenesis of the lung and enhances expression of surfactant proteins by alveolar type II cells. We investigated expression of two TTF-1 mRNA transcripts, generated by alternative start sites and coding for 42- and 46-kD protein isoforms in the mouse, during hormone-induced differentiation of human ...
متن کاملThyroid transcription factor-1 (TTF1)
A strong, distinct nuclear staining reaction of type II pneumocytes, Clara cells and basal cells of the terminal bronchioles in the lung. A moderate to strong, distinct nuclear staining reaction of the columnar epithelial cells of the terminal bronchioles in the lung. A strong, distinct nuclear staining reaction of all follicular epithelial cells in the thyroid gland. A strong nuclear s...
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Background: Elevated level of plasma homocysteine has been related to various diseases. Patients with hyperhomocysteinemia can develop hepatic steatosis and fibrosis. We hypothesized that oxidative stress induced by homocysteine might play an important role in pathogenesis of liver injury. Also, the cellular response designed to combat oxidative stress is primarily controlled by the transcripti...
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AIMS To discover whether variations in thyroid transcription factor 1 (TTF-1) staining in different subtypes and patterns of pulmonary adenocarcinoma are related to the putative origin of the tumour. In addition, to confirm the specificity of TTF-1 for pulmonary (as opposed to other sites) adenocarcinoma, to examine the possible prognostic relevance of TTF-1 positivity in lung cancer, and to re...
متن کاملTranscription factor Etv5 is essential for the maintenance of alveolar type II cells.
Alveolar type II (AT2) cell dysfunction contributes to a number of significant human pathologies including respiratory distress syndrome, lung adenocarcinoma, and debilitating fibrotic diseases, but the critical transcription factors that maintain AT2 cell identity are unknown. Here we show that the E26 transformation-specific (ETS) family transcription factor Etv5 is essential to maintain AT2 ...
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ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2007
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2006-0207oc